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Vytorin 10 80 mg is restricted to patients who have been taking vytorin 10 80 mg chronically for example, for 12 months or more without evidence of muscle toxicity because the 10 80 mg dose is associated with increased risk of muscle toxicity, including rhabdomyolysis.

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Due to the increased risk of myopathy, including rhabdomyolysis, associated with the 10 80-mg dose of vytorin, patients unable to achieve their ldl-c goal utilizing the 10 40-mg dose of vytorin should not be titrated to the 10 80-mg dose, but should be placed on alternative ldl-c-lowering treatment s that provides greater ldl-c lowering.

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One positive outcome of the new study was that it showed no apparent adverse effects associated with vytorin, he added.

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